ABSTRACT
Coronavirus Disease 2019 (COVID-19), caused by the coronavirus, since its start in Wuhan a city in China has spread like a wild fire and created havoc all over the globe. Initially, the disease was thought to be causing only respiratory complication, but gradually it was found to be causing multiorgan complication. Due to the hypercoagulable property of coronavirus, it has shown neurological, cardiological and endocrine complication. Recently, the effect of the virus on endocrine system has also been noted. Evidence has shown that COVID-19 can hamper the hypothalamo-pituitary axis resulting in altered adrenal response to stress. The immune-mediated damage to the endocrine glands results in subacute thyroiditis. The presence of Angiotensin Converting Enzyme 2 (ACE 2) receptors on various tissues could be the cause of this immune mediated damage. COVID-19 has also precipitated hyperglycaemia and in few cases, uncovered the insulin resistance in previously undiagnosed cases. It is crucial to have knowledge about the impact of endocrine system, as it is the powerhouse of the body.